用ChatGPT挽救八歲狗狗生命的故事
以下內容，來自兩份澳州報紙，相關連結放在文章最後。
In 2024, Rosie, an eight-year-old rescue dog in Sydney, was diagnosed with an aggressive form of mast cell cancer that had stopped responding to surgery and chemotherapy. Vets estimated she had only months to live.
2024 年，八歲的救援犬 Rosie 被診斷出患有侵襲性肥大細胞瘤，且對手術和化療不再有效。獸醫估計她只剩幾個月生命。
Her owner, Paul Conyngham, a Sydney tech entrepreneur experienced in machine learning but without any formal biology training, decided to try something extraordinary.
她的主人 Paul Conyngham 是一名雪梨科技企業家，有機器學習背景，但沒有正式的生物學訓練，他決定嘗試一種非常規方法。
Paul had Rosie’s tumour and healthy tissue sequenced to identify genetic mutations driving her cancer. He then used AI tools — including ChatGPT and **DeepMind’s AlphaFold — to analyze the genetic data and model protein structures to find targetable mutations.
Paul 先對 Rosie 的腫瘤與健康組織做 DNA 定序，找出驅動癌症的基因突變，然後用 AI 工具（包括 ChatGPT 與 DeepMind 的 AlphaFold）來分析這些基因資料，並預測突變蛋白質的結構以鎖定治療標靶。
With that analysis in hand, he collaborated with researchers at the UNSW RNA Institute led by Prof. Páll Thordarson to synthesize a custom-made mRNA vaccine tailored to Rosie’s tumour.
基於這些分析，他與新南威爾斯大學（UNSW）RNA 研究所的 Prof. Páll Thordarson 合作，製作了一支針對 Rosie 腫瘤的客製化 mRNA 疫苗。
Rosie received the first dose in December 2025, followed by boosters. Within weeks, most of her tumours showed marked shrinkage, with one large tumour reduced by around half.
Rosie 在 2025 年 12 月打了第一劑疫苗，並陸續補打追加劑。幾週內，她多數的腫瘤顯著縮小，其中一顆大腫瘤甚至縮小了約一半。
Scientists involved called this the first time a personalized cancer vaccine was designed for a dog, illustrating the potential of combining AI with genomic science for rapid personalized therapies.
報道指今年一月，可愛的狗狗已經恢復行動力，可以奔跑追趕了。
參與的科學家稱這是 全球首次為一隻狗設計的個人化癌症疫苗，顯示出 AI 結合基因科學能快速推動個人化療法的可能性。
類似人類癌症疫苗研發（補充背景）
雖然現階段主要是動物案例，但mRNA 個人化癌症疫苗本身也是人類腫瘤免疫研究的熱點，例如 BioNTech 與 Genentech 正在開發的個人化 neoantigen mRNA 疫苗，可以刺激免疫系統針對殘留癌細胞反應。